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SETD2 Mutations Do Not Contribute to Clonal Fitness in Response to Chemotherapy in Childhood B Acute Lymphoblastic Leukemia (WES)

GSE231723 Homo sapiens Other 12 samples Submitted 2024/05/01 Platform GPL24676
Summary
To investigate the impact of SETD2 mutations on clonal fitness in B actue lymphoblastic leukemia we generated cells lines with SETD KO using CRISPR/Cas9 system. We then performed phenotypic based assays as well as gene expression profiling, mutation burden, and chromtain accessibilty analysis using data obtained from RNA-seq, Whole exom sequencing following drug traetment, and ATAC-seq.
Published in
SETD2 mutations do not contribute to clonal fitness in response to chemotherapy in childhood B cell acute lymphoblastic leukemia
Contreras Yametti GP, Robbins G, Chowdhury A et al. · Leukemia & lymphoma 2024 · PMID 37874744 · doi:10.1080/10428194.2023.2273752
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Also filed as BioProject PRJNA967354. Searching any of these in the dataset finder brings you back here.

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