GEO series
Single Nuclei RNA-Seq to map progression of non-alcoholic fatty liver disease (NAFLD) in patients II
GSE202379
Homo sapiens
Expression profiling by high throughput sequencing
59 samples
Submitted 2024/04/04
Platform GPL24676
Summary
Non-alcoholic fatty liver disease (NAFLD) is of increasing prevalence and concern. NAFLD can progress to non-alcoholic steatohepatitis (NASH), to cirrhosis and finally to end-stage liver disease where liver transplantation is required. We aimed to characterise this progression by performing single nuclei transcriptomic analysis of liver biopsies taken from patients across the disease spectrum. We have observed that hepatocytes are the cell type affected mostly by the disease and describe plasticity between cell types which may represent a regenerative process.
Published in
Gribben C, Galanakis V, Calderwood A et al.
· Nature 2024
· PMID 38778114
· doi:10.1038/s41586-024-07465-2
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE202379_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 59 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA835824 and SRA study SRP374021. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 59 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM6112209 P70-NASH w/o cirrhosis-B-SITTA3
- GSM6112210 P48-NASH w/o cirrhosis-B-SITTA8
- GSM6112211 P77-NASH w/o cirrhosis-B-SITTB8
- GSM6112212 P78-NAFLD-B-SITTC8
- GSM6112213 P62-NASH w/o cirrhosis-B-SITTD3
- GSM6112214 P12-NASH with cirrhosis-B-SITTD8
- GSM6112215 P22-NASH with cirrhosis-B-SITTE8
- GSM6112216 P83-NASH w/o cirrhosis-B-SITTF12
- GSM6112217 P67-NASH w/o cirrhosis-B-SITTF3
- GSM6112218 P52-NASH w/o cirrhosis-C-SITTD9
- GSM6112219 P53-NASH w/o cirrhosis-C-SITTE9
- GSM6112220 P54-NASH w/o cirrhosis-C-SITTF9
- GSM6112221 P71-NASH w/o cirrhosis-C-SITTG1
- GSM6112222 P64-NASH w/o cirrhosis-D-SITTA6
- GSM6112223 P6-NAFLD-D-SITTA7
- GSM6112224 P49-NASH w/o cirrhosis-D-SITTA9
- GSM6112225 P50-NASH w/o cirrhosis-D-SITTB9
- GSM6112226 P51-NAFLD-D-SITTC9
- GSM6112227 P68-NASH with cirrhosis-D-SITTD5
- GSM6112228 P75-NASH with cirrhosis-D-SITTE5
- GSM6112229 P76-NASH w/o cirrhosis-D-SITTF5
- GSM6112230 P60-NAFLD-D-SITTG5
- GSM6112231 P7-NASH w/o cirrhosis-E-SITTB5
- GSM6112232 P19-NASH w/o cirrhosis-E-SITTB6
- GSM6112233 P8-NASH w/o cirrhosis-E-SITTC5
- GSM6112234 P20-NASH w/o cirrhosis-E-SITTC6
- GSM6112235 P9-NASH w/o cirrhosis-E-SITTD5
- GSM6112236 P21-NASH w/o cirrhosis-E-SITTD6
- GSM6112237 PHL2-Healthy control-E-SITTD9
- GSM6112238 PCL103-end stage-E-SITTE9
- GSM6112239 P15-NASH w/o cirrhosis-E-SITTF5
- GSM6112240 PCL103-end stage-E-SITTF9
- GSM6112241 P16-NASH w/o cirrhosis-E-SITTG5
- GSM6112242 PCL103-end stage-F-SITTD3
- GSM6112243 P30-Healthy control-G-SITTB7
- GSM6112244 P98-Healthy control-G-SITTF7
- GSM6112245 PCL16-end stage-H-SITTB12
- GSM6112246 PCL16-end stage-H-SITTC12
- GSM6112247 PCL16-end stage-H-SITTD12
- GSM6112248 PCL104-end stage-I-SITTD1
+ 19 more — browse all 59 samples with per-sample file links →
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