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Multiregional single-cell profiling reveals extensive field cancerization and an immunosuppressive microenvironment in oral squamous cell carcinoma

GSE198315 Homo sapiens Expression profiling by high throughput sequencing 36 samples Submitted 2025/06/19 Platform GPL20795
Summary
Oral squamous cell carcinoma (OSCC) is highly heterogeneous and metastatic, and the mechanisms driving OSCC development, progression, and metastasis are poorly understood. We performed multiregional single-cell RNA sequencing on 268,131 cells obtained from tumor core, tumor periphery, adjacent non-tumor tissue, and metastatic lymph node samples from 10 patients with human papillomavirus (HPV)–negative metastatic OSCC.
Published in
Multiregional single-cell transcriptomics reveals an association between partial EMT and immunosuppressive states in oral squamous cell carcinoma
Kim S, Kee HJ, Kim D et al. · iScience 2025 · PMID 41054545 · doi:10.1016/j.isci.2025.112988
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Direct links to NCBI, no account and no request form: the whole study as GSE198315_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 36 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA814536 and SRA study SRP363421. Searching any of these in the dataset finder brings you back here.

Study design
36 conditions, each sampled once — no replicated groups

Read from 36 sample titles: 36 distinct titles with little repetition. Check it against the sample list below before relying on it.

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