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Single-nucleus Multiome Profiling of Infant and Adult Human Spleen

GSE311423 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 10 samples Submitted 2026/01/01 Platform GPL34281
Summary
We performed joint single-cell RNA and ATAC-seq on T cells from spleen of infant and adult donors.
Published in
Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells
Szabo PA, Levitin HM, Nargund S et al. · Nature immunology 2026 · PMID 42230957 · doi:10.1038/s41590-026-02535-1
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Direct links to NCBI, no account and no request form: the whole study as GSE311423_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 10 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1369441 and SRA study SRP648886. Searching any of these in the dataset finder brings you back here.

Study design
10 conditions, each sampled once — no replicated groups

Read from 10 sample titles: 10 distinct titles with little repetition. Check it against the sample list below before relying on it.

Samples in this study
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