GEO series
Multi-omics Sequencing reveals Epigenetic Regulation in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma [m6A-seq]
Summary
Cutaneous squamous cell carcinoma (cSCC) is an important type of skin cancer. It is difficult to diagnose and treat, which seriously endanger people’s the physical and mental health. Actinic keratosis (AK) induced by ultraviolet radiation is the precancerous lesion of cSCC. The mechanism of occurrence and development of cSCC is still unclear, and the research on epigenetics is even less. In this project, we intend to study the mechanism of cSCC, especially the transformation from normal skin to AK, cSCC and the metastasis in late stage of cSCC, using multi-omics sequencing technology with experimental methods. Through the integrated analysis of multi-omics information such as DNA methylation, RNA methylation, chromatin accessibility and transcriptome, we obtained the epigenetic map of different stages of cSCC and identified the potential key epigenetic driving factors for cSCC. This project provided an important scientific basis for the clinical treatment and drug development of cSCC, as well as method reference for the study of other cancers.
Published in
Sun YZ, Zou DD, Li XJ et al.
· Journal of translational medicine 2025
· PMID 41233828
· doi:10.1186/s12967-025-07262-z
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE277275_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 40 samples.
Also filed as BioProject PRJNA1161632. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from 40 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8517627 AK_P6_m6a_IP
- GSM8517628 AK_P6_m6a_input
- GSM8517629 AK_P7_m6a_IP
- GSM8517630 AK_P7_m6a_input
- GSM8517631 AK_P8_m6a_IP
- GSM8517632 AK_P8_m6a_input
- GSM8517633 AK_P9_m6a_IP
- GSM8517634 AK_P9_m6a_input
- GSM8517635 AK_P10_m6a_IP
- GSM8517636 AK_P10_m6a_input
- GSM8517637 Normal_P6_m6a_IP
- GSM8517638 Normal_P6_m6a_input
- GSM8517639 Normal_P7_m6a_IP
- GSM8517640 Normal_P7_m6a_input
- GSM8517641 Normal_P8_m6a_IP
- GSM8517642 Normal_P8_m6a_input
- GSM8517643 Normal_P9_m6a_IP
- GSM8517644 Normal_P9_m6a_input
- GSM8517645 Normal_P10_m6a_IP
- GSM8517646 Normal_P10_m6a_input
- GSM8517647 cSCC_P1_m6a_IP
- GSM8517648 cSCC_P1_m6a_input
- GSM8517649 cSCC_P2_m6a_IP
- GSM8517650 cSCC_P2_m6a_input
- GSM8517651 cSCC_P3_m6a_IP
- GSM8517652 cSCC_P3_m6a_input
- GSM8517653 cSCC_P4_m6a_IP
- GSM8517654 cSCC_P4_m6a_input
- GSM8517655 cSCC_P5_m6a_IP
- GSM8517656 cSCC_P5_m6a_input
- GSM8517657 Normal_P1_m6a_IP
- GSM8517658 Normal_P1_m6a_input
- GSM8517659 Normal_P2_m6a_IP
- GSM8517660 Normal_P2_m6a_input
- GSM8517661 Normal_P3_m6a_IP
- GSM8517662 Normal_P3_m6a_input
- GSM8517663 Normal_P4_m6a_IP
- GSM8517664 Normal_P4_m6a_input
- GSM8517665 Normal_P5_m6a_IP
- GSM8517666 Normal_P5_m6a_input
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