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ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats [RNA-Seq]

GSE218866 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 12 samples Submitted 2025/01/30 Platform GPL18573Platform GPL19057
Summary
ZBTB24 has emerged as a key player in DNA methylation, immunity and development. To explore these multiple facets of ZBTB24 functions, we performed and integrated multi-omics analyses in mouse and human cellular systems relevant for the physiopathological features of the ICF2 syndrome, a rare genetic disease caused by ZBTB24 mutations.
Published in
ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats
Grillo G, Boyarchuk E, Mihic S et al. · Human molecular genetics 2025 · PMID 39562305 · doi:10.1093/hmg/ddae163
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Direct links to NCBI, no account and no request form: the whole study as GSE218866_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA906042 and SRA study SRP410203. Searching any of these in the dataset finder brings you back here.

Study design
12 conditions, each sampled once — no replicated groups

Read from 12 sample titles: 12 distinct titles with little repetition. Check it against the sample list below before relying on it.

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